منابع مشابه
Glial cells and chronic pain.
Over the past few years, the control of pain exerted by glial cells has emerged as a promising target against pathological pain. Indeed, changes in glial phenotypes have been reported throughout the entire nociceptive pathway, from peripheral nerves to higher integrative brain regions, and pharmacological inhibition of such glial reactions reduces the manifestation of pain in animal models. Thi...
متن کاملThe Role of Glial Cells in Chronic Pain
INTRODUCTION Pain management remains a significant health concern, especially for those who suffer from chronic pain. Also known as neuropathic pain, this type of pain usually follows injury, surgery, infection, or chemotherapy (Marx, 2004). Chronic pain, or pain that persists beyond the natural course of healing, affects over five million people in the United States (Tawfik et al., 2007) and c...
متن کاملEvidence for brain glial activation in chronic pain patients.
Although substantial evidence has established that microglia and astrocytes play a key role in the establishment and maintenance of persistent pain in animal models, the role of glial cells in human pain disorders remains unknown. Here, using the novel technology of integrated positron emission tomography-magnetic resonance imaging and the recently developed radioligand (11)C-PBR28, we show inc...
متن کاملThe contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain
BACKGROUND Clinical studies of osteoarthritis (OA) suggest central sensitization may contribute to the chronic pain experienced. This preclinical study used the monosodium iodoacetate (MIA) model of OA joint pain to investigate the potential contribution of spinal sensitization, in particular spinal glial cell activation, to pain behaviour in this model. Experimental OA was induced in the rat b...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2010
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858409360822